Veterans Affairs Seamless Phase II/III Randomized Trial of STAndard Systemic theRapy With or Without PET-directed Local Therapy for Oligometastatic pRosTate Cancer

Conditions

• Prostate Cancer
• Oligometastasis
• Oligorecurrence
• Recurrent Prostate Cancer
• Metastatic Prostate Cancer
• De Novo Prostate Cancer

Interventions

• PROCEDURE: PET-directed Local Therapy using Surgery
• RADIATION: PET-directed Local Therapy using Radiation
• OTHER: Salvage Local Therapy for locally recurrent disease
• DRUG: Goserelin, Histrelin, Leuprolide & Triptorelin
• DRUG: ADT + Nilutamide, Flutamide, & Bicalutamide
• DRUG: Degarelix & Relugolix
• DRUG: ADT + Docetaxel +/- prednisone
• DRUG: ADT + Abiraterone + Prednisone
• DRUG: ADT + Abiraterone + Methylprednisolone
• DRUG: ADT + Apalutamide
• DRUG: ADT + Enzalutamide
• RADIATION: Prostate-directed Radiation for De novo oligometastatic prostate cancer

Sponsor

VA Office of Research and Development