# A Study to Examine the Safety, Tolerability, and Pharmacokinetics of Single- and Multiple-ascending Doses of ACT-777991 in Healthy Subjects

> **NCT04798209** · PHASE1 · COMPLETED · sponsor: **Idorsia Pharmaceuticals Ltd.** · enrollment: 70 (actual)

## Conditions studied

- Healthy

## Interventions

- **DRUG:** ACT-777991 (SAD)
- **DRUG:** ACT-777991 (MAD)
- **DRUG:** Placebo (SAD)
- **DRUG:** Placebo (MAD)
- **DRUG:** 14C-ACT-777991 microtracer (SAD - Absolute Bioavailability)
- **DRUG:** Microtracer matching placebo (SAD - Absolute Bioavailability)
- **DRUG:** 14C-ACT-777991 microtracer (MAD - ADME)
- **DRUG:** Microtracer matching placebo (MAD - ADME)

## Key facts

- **NCT ID:** NCT04798209
- **Lead sponsor:** Idorsia Pharmaceuticals Ltd.
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2021-01-29
- **Primary completion:** 2022-01-26
- **Final completion:** 2022-05-21
- **Target enrollment:** 70 (ACTUAL)
- **Last updated:** 2022-06-21


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04798209

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04798209, "A Study to Examine the Safety, Tolerability, and Pharmacokinetics of Single- and Multiple-ascending Doses of ACT-777991 in Healthy Subjects". Retrieved via AI Analytics 2026-06-01 from https://api.ai-analytics.org/clinical/NCT04798209. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*