# Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Ability

> **NCT04804644** · PHASE3 · RECRUITING · sponsor: **NRG Oncology** · enrollment: 200 (estimated)

## Conditions studied

- Metastatic Lung Small Cell Carcinoma
- Metastatic Malignant Neoplasm in the Brain
- Recurrent Lung Small Cell Carcinoma
- Stage IV Lung Cancer AJCC v8

## Interventions

- **PROCEDURE:** Biospecimen Collection
- **PROCEDURE:** Magnetic Resonance Imaging
- **DRUG:** Memantine Hydrochloride
- **OTHER:** Neurocognitive Assessment
- **RADIATION:** Stereotactic Radiosurgery
- **OTHER:** Survey Administration
- **RADIATION:** Whole-Brain Radiotherapy

## Key facts

- **NCT ID:** NCT04804644
- **Lead sponsor:** NRG Oncology
- **Sponsor class:** OTHER
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2021-06-08
- **Primary completion:** 2028-07-01
- **Final completion:** 2030-07-01
- **Target enrollment:** 200 (ESTIMATED)
- **Last updated:** 2026-05-04

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04804644

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04804644, "Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Ability". Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/clinical/NCT04804644. Licensed CC0.

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