# Treatment Effects of Subcutaneous Injections of Pentosan Polysulfate Sodium vs Placebo in Participants With Knee OA Pain

> **NCT04809376** · PHASE2,PHASE3 · ACTIVE_NOT_RECRUITING · sponsor: **Paradigm Biopharmaceuticals USA (INC)** · enrollment: 602 (actual)

## Conditions studied

- Osteoarthritis, Knee

## Interventions

- **DRUG:** Pentosan Polysulfate Sodium twice weekly
- **DRUG:** Placebo (Sodium Chloride Injection, 0.9%)
- **DRUG:** Pentosan Polysulfate Sodium Fixed Dose
- **DRUG:** Pentosan Polysulfate Sodium once weekly

## Key facts

- **NCT ID:** NCT04809376
- **Lead sponsor:** Paradigm Biopharmaceuticals USA (INC)
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE2,PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2021-10-19
- **Primary completion:** 2024-10-15
- **Final completion:** 2025-01-06
- **Target enrollment:** 602 (ACTUAL)
- **Last updated:** 2024-04-08


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04809376

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04809376, "Treatment Effects of Subcutaneous Injections of Pentosan Polysulfate Sodium vs Placebo in Participants With Knee OA Pain". Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/clinical/NCT04809376. Licensed CC0.

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