# Randomized Controlled Trial- Ablation Strategy for Paroxysmal Atrial Fibrillation - Trigger and Substrate Guided Wide Area Radiofrequency Ablation Compared to Pulsed Field Ablation Pulmonary Vein Isolation

> **NCT04823299** · NA · RECRUITING · sponsor: **Ottawa Heart Institute Research Corporation** · enrollment: 556 (estimated)

## Conditions studied

- Atrial Fibrillation
- Catheter Ablation
- Radiofrequency Catheter Ablation

## Interventions

- **PROCEDURE:** PVI-ONLY, CONTROL ARM
- **PROCEDURE:** PVI-PLUS ARM, INTERVENTIONAL ARM

## Key facts

- **NCT ID:** NCT04823299
- **Lead sponsor:** Ottawa Heart Institute Research Corporation
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2026-03-23
- **Primary completion:** 2029-03
- **Final completion:** 2030-03
- **Target enrollment:** 556 (ESTIMATED)
- **Last updated:** 2026-04-29

## Collaborators

- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04823299

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04823299, "Randomized Controlled Trial- Ablation Strategy for Paroxysmal Atrial Fibrillation - Trigger and Substrate Guided Wide Area Radiofrequency Ablation Compared to Pulsed Field Ablation Pulmonary Vein Isolation". Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/clinical/NCT04823299. Licensed CC0.

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