Efficacy and Safety of Selective Digestive Decontamination in the ICU With High Rates of Antibiotic-resistant Bacteria

Conditions

• Pneumonia, Ventilator-Associated
• Pneumonia
• Bloodstream Infection
• Sepsis
• Respiratory Distress Syndrome
• Respiratory Tract Infections
• Critical Illness

Interventions

• DRUG: Oral Paste(0,5 g) containing 10 mg of polymyxin B, 10 mg of gentamycin and 150 mg of amphotericine B or 500 000 U of nistatin q6h
• DRUG: Suspension (10 ml) containing 100 mg of polymyxin B, 80 mg of gentamycin, 350 mg of amphotericine B or 8000000 U of nistation and 500 mg of vancomycin q6h
• DRUG: Intravenous Antibacterial Agent - a 3-day course of systemic cefotaxime 1 g q6h or ceftriaxone 1 g qd

Sponsor

MEDSI Clinical Hospital 1, ICU