# Neural Mechanisms of Immersive Virtual Reality in Chronic Pain

> **NCT04851301** · PHASE1,PHASE2 · ACTIVE_NOT_RECRUITING · sponsor: **University of Maryland, Baltimore** · enrollment: 259 (actual)

## Conditions studied

- Pain
- Virtual Reality
- Placebo
- Temporomandibular Disorder

## Interventions

- **BEHAVIORAL:** Active Virtual Reality
- **BEHAVIORAL:** sham Virtual Reality
- **OTHER:** No Intervention
- **DRUG:** Naloxone
- **OTHER:** Saline
- **OTHER:** Natural history

## Key facts

- **NCT ID:** NCT04851301
- **Lead sponsor:** University of Maryland, Baltimore
- **Sponsor class:** OTHER
- **Phase:** PHASE1,PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2021-11-01
- **Primary completion:** 2025-12-30
- **Final completion:** 2026-11-30
- **Target enrollment:** 259 (ACTUAL)
- **Last updated:** 2026-02-27


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04851301

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04851301, "Neural Mechanisms of Immersive Virtual Reality in Chronic Pain". Retrieved via AI Analytics 2026-07-06 from https://api.ai-analytics.org/clinical/NCT04851301. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*