# Safely Stopping Pre-medications in Patients With Breast Cancer Who Are Receiving Paclitaxel

> **NCT04862585** · PHASE2,PHASE3 · COMPLETED · sponsor: **Ohio State University Comprehensive Cancer Center** · enrollment: 130 (actual)

## Conditions studied

- Anatomic Stage 0 Breast Cancer AJCC v8
- Anatomic Stage I Breast Cancer AJCC v8
- Anatomic Stage IA Breast Cancer AJCC v8
- Anatomic Stage IB Breast Cancer AJCC v8
- Anatomic Stage II Breast Cancer AJCC v8
- Anatomic Stage IIA Breast Cancer AJCC v8
- Anatomic Stage IIB Breast Cancer AJCC v8
- Anatomic Stage III Breast Cancer AJCC v8
- Anatomic Stage IIIA Breast Cancer AJCC v8
- Anatomic Stage IIIB Breast Cancer AJCC v8
- Anatomic Stage IIIC Breast Cancer AJCC v8
- Anatomic Stage IV Breast Cancer AJCC v8
- Breast Carcinoma
- Prognostic Stage 0 Breast Cancer AJCC v8
- Prognostic Stage I Breast Cancer AJCC v8
- Prognostic Stage IA Breast Cancer AJCC v8
- Prognostic Stage IB Breast Cancer AJCC v8
- Prognostic Stage II Breast Cancer AJCC v8
- Prognostic Stage IIA Breast Cancer AJCC v8
- Prognostic Stage IIB Breast Cancer AJCC v8
- Prognostic Stage III Breast Cancer AJCC v8
- Prognostic Stage IIIA Breast Cancer AJCC v8
- Prognostic Stage IIIB Breast Cancer AJCC v8
- Prognostic Stage IIIC Breast Cancer AJCC v8
- Prognostic Stage IV Breast Cancer AJCC v8

## Interventions

- **DRUG:** Cimetidine
- **DRUG:** Dexamethasone
- **DRUG:** Diphenhydramine
- **DRUG:** Famotidine
- **DRUG:** Paclitaxel
- **OTHER:** Quality-of-Life Assessment
- **DRUG:** Ranitidine

## Key facts

- **NCT ID:** NCT04862585
- **Lead sponsor:** Ohio State University Comprehensive Cancer Center
- **Sponsor class:** OTHER
- **Phase:** PHASE2,PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2021-10-07
- **Primary completion:** 2024-06-21
- **Final completion:** 2024-06-21
- **Target enrollment:** 130 (ACTUAL)
- **Last updated:** 2025-08-20


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04862585

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04862585, "Safely Stopping Pre-medications in Patients With Breast Cancer Who Are Receiving Paclitaxel". Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/clinical/NCT04862585. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*