# Nasal High-flow Compared to Non-invasive Ventilation in Treatment of Acute Acidotic Hypercapnic Exacerbation of Chronic Obstructive Pulmonary Disease

> **NCT04881409** · NA · UNKNOWN · sponsor: **University of Leipzig** · enrollment: 720 (estimated)

## Conditions studied

- COPD Exacerbation Acute

## Interventions

- **DEVICE:** Respiratory support with nasal high-flow (NHF)
- **DEVICE:** Respiratory support with non-invasive ventilation (NIV)

## Key facts

- **NCT ID:** NCT04881409
- **Lead sponsor:** University of Leipzig
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** UNKNOWN
- **Start date:** 2021-05-06
- **Primary completion:** 2024-02-06
- **Final completion:** 2024-10-06
- **Target enrollment:** 720 (ESTIMATED)
- **Last updated:** 2022-02-09


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04881409

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04881409, "Nasal High-flow Compared to Non-invasive Ventilation in Treatment of Acute Acidotic Hypercapnic Exacerbation of Chronic Obstructive Pulmonary Disease". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT04881409. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*