# Evaluation of Non-opioid Balanced General Anesthesia in Cardiac Surgery With Extracorporeal Circulation: a Randomized, Controlled, Multicenter Superiority Trial

> **NCT04886453** · PHASE3 · COMPLETED · sponsor: **Centre Hospitalier Universitaire Dijon** · enrollment: 321 (actual)

## Conditions studied

- Opioid-free Anesthesia
- Cardiac Surgery

## Interventions

- **DRUG:** Balanced general anesthesia without morphine
- **DRUG:** Standard general anesthesia balanced with morphine
- **OTHER:** Data collection
- **OTHER:** Assessment of pain
- **OTHER:** Recovery quality score

## Key facts

- **NCT ID:** NCT04886453
- **Lead sponsor:** Centre Hospitalier Universitaire Dijon
- **Sponsor class:** OTHER
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2021-08-30
- **Primary completion:** 2024-03-21
- **Final completion:** 2024-03-21
- **Target enrollment:** 321 (ACTUAL)
- **Last updated:** 2024-05-17


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04886453

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04886453, "Evaluation of Non-opioid Balanced General Anesthesia in Cardiac Surgery With Extracorporeal Circulation: a Randomized, Controlled, Multicenter Superiority Trial". Retrieved via AI Analytics 2026-06-04 from https://api.ai-analytics.org/clinical/NCT04886453. Licensed CC0.

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