# Study of Selinexor and Venetoclax in Combination With Chemotherapy in Pediatric and Young Adult Patients With Refractory or Relapsed Acute Myeloid Leukemia

> **NCT04898894** · PHASE1 · ACTIVE_NOT_RECRUITING · sponsor: **St. Jude Children's Research Hospital** · enrollment: 37 (actual)

## Conditions studied

- Acute Leukemia of Ambiguous Lineage in Relapse
- Acute Myeloid Leukemia, in Relapse
- Refractory Acute Leukemia of Ambiguous Lineage
- Refractory Acute Myeloid Leukemia

## Interventions

- **DRUG:** Venetoclax
- **DRUG:** Selinexor
- **DRUG:** Cytarabine
- **DRUG:** Fludarabine
- **BIOLOGICAL:** Filgrastim
- **DRUG:** Methotrexate
- **DRUG:** methotrexate/hydrocortisone/cytarabine

## Key facts

- **NCT ID:** NCT04898894
- **Lead sponsor:** St. Jude Children's Research Hospital
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2021-11-15
- **Primary completion:** 2023-07-12
- **Final completion:** 2027-09
- **Target enrollment:** 37 (ACTUAL)
- **Last updated:** 2026-04-28

## Collaborators

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- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04898894

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04898894, "Study of Selinexor and Venetoclax in Combination With Chemotherapy in Pediatric and Young Adult Patients With Refractory or Relapsed Acute Myeloid Leukemia". Retrieved via AI Analytics 2026-07-12 from https://api.ai-analytics.org/clinical/NCT04898894. Licensed CC0.

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