# HLA-Mismatched Unrelated Donor Hematopoietic Cell Transplantation With Post-Transplantation Cyclophosphamide

> **NCT04904588** · PHASE2 · ACTIVE_NOT_RECRUITING · sponsor: **Center for International Blood and Marrow Transplant Research** · enrollment: 300 (estimated)

## Conditions studied

- Acute Lymphoblastic Leukemia
- Acute Myelogenous Leukemia
- Mixed Phenotype Acute Leukemia
- Acute Leukemia
- Myelodysplastic Syndromes
- Chronic Myelogenous Leukemia
- Chronic Lymphocytic Leukemia
- Lymphoma

## Interventions

- **DRUG:** Busulfan
- **DRUG:** Busulfan
- **DRUG:** Fludarabine
- **RADIATION:** Total-body irradiation
- **DRUG:** Cyclophosphamide
- **DRUG:** Melphalan
- **PROCEDURE:** PBSC Hematopoietic Stem Cell Transplantation (HSCT)
- **PROCEDURE:** Bone Marrow Hematopoietic Stem Cell Transplantation
- **DRUG:** Post-transplant Cyclophosphamide
- **DRUG:** Mesna
- **DRUG:** Tacrolimus
- **DRUG:** Mycophenolate Mofetil
- **OTHER:** Patient-Reported Outcomes

## Key facts

- **NCT ID:** NCT04904588
- **Lead sponsor:** Center for International Blood and Marrow Transplant Research
- **Sponsor class:** NETWORK
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2021-09-30
- **Primary completion:** 2026-08
- **Final completion:** 2026-12
- **Target enrollment:** 300 (ESTIMATED)
- **Last updated:** 2026-03-18

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04904588

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04904588, "HLA-Mismatched Unrelated Donor Hematopoietic Cell Transplantation With Post-Transplantation Cyclophosphamide". Retrieved via AI Analytics 2026-06-24 from https://api.ai-analytics.org/clinical/NCT04904588. Licensed CC0.

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