# Systematic Escalation of diuREtics With Natriuresis in Heart Failure Patients: SERENA Trial

> **NCT04907123** · PHASE3 · UNKNOWN · sponsor: **University of Turin, Italy** · enrollment: 198 (estimated)

## Conditions studied

- Heart Failure

## Interventions

- **OTHER:** Intensive sodiuria-guided diuretic treatment
- **OTHER:** Standard diuretic treatment

## Key facts

- **NCT ID:** NCT04907123
- **Lead sponsor:** University of Turin, Italy
- **Sponsor class:** OTHER
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** UNKNOWN
- **Start date:** 2021-10
- **Primary completion:** 2024-10
- **Final completion:** 2025-01
- **Target enrollment:** 198 (ESTIMATED)
- **Last updated:** 2021-05-28


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04907123

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04907123, "Systematic Escalation of diuREtics With Natriuresis in Heart Failure Patients: SERENA Trial". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT04907123. Licensed CC0.

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