# Virtual Reality and Olfactory Stimuli Multimodal Intervention to Reduce Post-Operative Pain and Anxiety in Patients Undergoing Cardiothoracic Surgery

> **NCT04912531** · NA · RECRUITING · sponsor: **Massachusetts General Hospital** · enrollment: 80 (estimated)

## Conditions studied

- Postoperative Pain
- Anxiety Postoperative
- Opioid Use

## Interventions

- **DEVICE:** Virtual Realty using a Microsoft Hololens, Empatica HR wristband, and EEG
- **DEVICE:** Essence Olfactory Necklace
- **DEVICE:** Bedside Olfaction Device

## Key facts

- **NCT ID:** NCT04912531
- **Lead sponsor:** Massachusetts General Hospital
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2022-10-01
- **Primary completion:** 2028-05-31
- **Final completion:** 2028-06-30
- **Target enrollment:** 80 (ESTIMATED)
- **Last updated:** 2026-02-20


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04912531

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04912531, "Virtual Reality and Olfactory Stimuli Multimodal Intervention to Reduce Post-Operative Pain and Anxiety in Patients Undergoing Cardiothoracic Surgery". Retrieved via AI Analytics 2026-07-28 from https://api.ai-analytics.org/clinical/NCT04912531. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*