# Safety and Tolerability of Metformin in People With Tuberculosis (TB) and Human Immunodeficiency Virus (HIV)

> **NCT04930744** · PHASE2 · COMPLETED · sponsor: **University of Massachusetts, Worcester** · enrollment: 112 (actual)

## Conditions studied

- Tuberculosis
- Pulmonary Tuberculosis
- HIV Coinfection

## Interventions

- **DRUG:** Isoniazid
- **DRUG:** Rifampicin
- **DRUG:** Ethambutol
- **DRUG:** Pyrazinamide
- **DRUG:** Metformin hydrochoride

## Key facts

- **NCT ID:** NCT04930744
- **Lead sponsor:** University of Massachusetts, Worcester
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2021-08-26
- **Primary completion:** 2025-04-29
- **Final completion:** 2025-08-15
- **Target enrollment:** 112 (ACTUAL)
- **Last updated:** 2026-04-06

## Collaborators

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## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04930744

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04930744, "Safety and Tolerability of Metformin in People With Tuberculosis (TB) and Human Immunodeficiency Virus (HIV)". Retrieved via AI Analytics 2026-06-23 from https://api.ai-analytics.org/clinical/NCT04930744. Licensed CC0.

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