# The GUARDIAN Trial - Vasopressor Sub-Study

> **NCT04934748** · PHASE4 · ENROLLING_BY_INVITATION · sponsor: **The University of Texas Health Science Center, Houston** · enrollment: 6254 (estimated)

## Conditions studied

- Blood Pressure

## Interventions

- **PROCEDURE:** Routine Blood Pressure Management
- **PROCEDURE:** Tight Blood Pressure Management
- **DRUG:** Phenylephrine
- **DRUG:** Norepinephrine

## Key facts

- **NCT ID:** NCT04934748
- **Lead sponsor:** The University of Texas Health Science Center, Houston
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** ENROLLING_BY_INVITATION
- **Start date:** 2021-07-25
- **Primary completion:** 2026-12-31
- **Final completion:** 2027-04-25
- **Target enrollment:** 6254 (ESTIMATED)
- **Last updated:** 2025-08-29


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04934748

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04934748, "The GUARDIAN Trial - Vasopressor Sub-Study". Retrieved via AI Analytics 2026-06-26 from https://api.ai-analytics.org/clinical/NCT04934748. Licensed CC0.

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