# A Study to See if Memantine Protects the Brain During Radiation Therapy Treatment for a Brain Tumor

> **NCT04939597** · PHASE3 · ACTIVE_NOT_RECRUITING · sponsor: **Children's Oncology Group** · enrollment: 192 (estimated)

## Conditions studied

- Central Nervous System Carcinoma

## Interventions

- **PROCEDURE:** Biospecimen Collection
- **PROCEDURE:** Cognitive Assessment
- **PROCEDURE:** Magnetic Resonance Imaging
- **DRUG:** Memantine Hydrochloride
- **DRUG:** Placebo Administration
- **OTHER:** Questionnaire Administration

## Key facts

- **NCT ID:** NCT04939597
- **Lead sponsor:** Children's Oncology Group
- **Sponsor class:** NETWORK
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2022-05-10
- **Primary completion:** 2026-06-30
- **Final completion:** 2027-09-30
- **Target enrollment:** 192 (ESTIMATED)
- **Last updated:** 2025-12-22


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04939597

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04939597, "A Study to See if Memantine Protects the Brain During Radiation Therapy Treatment for a Brain Tumor". Retrieved via AI Analytics 2026-06-23 from https://api.ai-analytics.org/clinical/NCT04939597. Licensed CC0.

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