# Sustained Mood Improvement With Laughing Gas Exposure: A Randomized Controlled Pilot Trial

> **NCT04957368** · PHASE4 · COMPLETED · sponsor: **Unity Health Toronto** · enrollment: 40 (actual)

## Conditions studied

- Treatment Resistant Depression
- Major Depressive Disorder

## Interventions

- **DRUG:** Nitrous Oxide 99 %
- **DRUG:** Oxygen + Midazolam

## Key facts

- **NCT ID:** NCT04957368
- **Lead sponsor:** Unity Health Toronto
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2021-11-03
- **Primary completion:** 2024-02-27
- **Final completion:** 2024-02-27
- **Target enrollment:** 40 (ACTUAL)
- **Last updated:** 2024-05-08


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04957368

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04957368, "Sustained Mood Improvement With Laughing Gas Exposure: A Randomized Controlled Pilot Trial". Retrieved via AI Analytics 2026-06-24 from https://api.ai-analytics.org/clinical/NCT04957368. Licensed CC0.

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