# China Stroke Primary Prevention Trial 2 for Participants With Hypertension and MTHFR 677 TT Genotype

> **NCT04974151** · PHASE4 · RECRUITING · sponsor: **Shenzhen Ausa Pharmed Co.,Ltd** · enrollment: 24000 (estimated)

## Conditions studied

- Hypertension
- MTHFR 677 TT Genotype

## Interventions

- **DRUG:** Amlodipine besylate
- **DRUG:** Amlodipine besylate And Folic Acid
- **DRUG:** 5-methyltetrahydrofolate (5-MTHF)
- **DRUG:** Amlodipine placebo
- **DRUG:** Amlodipine folic acid placebo
- **DRUG:** 5-MTHF Placebos

## Key facts

- **NCT ID:** NCT04974151
- **Lead sponsor:** Shenzhen Ausa Pharmed Co.,Ltd
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2024-08-22
- **Primary completion:** 2029-06-30
- **Final completion:** 2029-06-30
- **Target enrollment:** 24000 (ESTIMATED)
- **Last updated:** 2025-02-26

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## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04974151

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04974151, "China Stroke Primary Prevention Trial 2 for Participants With Hypertension and MTHFR 677 TT Genotype". Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/clinical/NCT04974151. Licensed CC0.

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