# Glutamate and Opioid Mechanisms of Antidepressant Response to Ketamine

> **NCT04977674** · EARLY_PHASE1 · COMPLETED · sponsor: **King's College London** · enrollment: 27 (actual)

## Conditions studied

- Depressive Disorder, Treatment-Resistant

## Interventions

- **DRUG:** Naltrexone
- **DRUG:** Placebo
- **DRUG:** Ketamine

## Key facts

- **NCT ID:** NCT04977674
- **Lead sponsor:** King's College London
- **Sponsor class:** OTHER
- **Phase:** EARLY_PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2021-09-27
- **Primary completion:** 2023-02-13
- **Final completion:** 2023-02-20
- **Target enrollment:** 27 (ACTUAL)
- **Last updated:** 2023-03-02


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04977674

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04977674, "Glutamate and Opioid Mechanisms of Antidepressant Response to Ketamine". Retrieved via AI Analytics 2026-06-24 from https://api.ai-analytics.org/clinical/NCT04977674. Licensed CC0.

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