# Cannabinoid Interactions With Central and Peripheral Pain Mechanisms in Osteoarthritis of the Knee

> **NCT04992624** · PHASE2 · RECRUITING · sponsor: **Steven E Harte, PhD** · enrollment: 200 (estimated)

## Conditions studied

- Osteoarthritis, Knee
- Osteoarthritis of the Knee

## Interventions

- **DRUG:** Placebo
- **DRUG:** Cannabidiol (CBD)
- **DRUG:** Tetrahydrocannabinol (Marinol® or generic equivalent (e.g., dronabinol)

## Key facts

- **NCT ID:** NCT04992624
- **Lead sponsor:** Steven E Harte, PhD
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2022-02-22
- **Primary completion:** 2026-10-22
- **Final completion:** 2026-10-31
- **Target enrollment:** 200 (ESTIMATED)
- **Last updated:** 2025-09-02

## Collaborators

- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04992624

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04992624, "Cannabinoid Interactions With Central and Peripheral Pain Mechanisms in Osteoarthritis of the Knee". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT04992624. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*