Testing the Safety and Efficacy of the Addition of a New Anti-cancer Drug, ZEN003694, to Chemotherapy Treatment (Cisplatin and Etoposide or Carboplatin and Paclitaxel) for Adult and Pediatric Patients (12-17 Years) With NUT Carcinoma

NCT05019716 · clinicaltrials.gov ↗

PHASE1,PHASE2

Phase

RECRUITING

Status

36

Enrollment

NIH

Sponsor class

Conditions

Advanced NUT Carcinoma
Metastatic NUT Carcinoma
Unresectable NUT Carcinoma

Interventions

DRUG: BET Bromodomain Inhibitor ZEN-3694
PROCEDURE: Biopsy Procedure
PROCEDURE: Biospecimen Collection
DRUG: Carboplatin
DRUG: Cisplatin
DRUG: Etoposide
PROCEDURE: Imaging Procedure
DRUG: Paclitaxel

Sponsor

National Cancer Institute (NCI)