# Natural History Study in Adult-Onset Leukoencephalopathy With Axonal Spheroids and Pigmented Glia

> **NCT05020743** · — · TERMINATED · sponsor: **Vigil Neuroscience, Inc.** · enrollment: 56 (actual)

## Conditions studied

- ALSP

## Interventions

- **OTHER:** No intervention

## Key facts

- **NCT ID:** NCT05020743
- **Lead sponsor:** Vigil Neuroscience, Inc.
- **Sponsor class:** INDUSTRY
- **Phase:** —
- **Study type:** OBSERVATIONAL
- **Status:** TERMINATED
- **Start date:** 2021-09-13
- **Primary completion:** 2025-05-30
- **Final completion:** 2025-05-30
- **Target enrollment:** 56 (ACTUAL)
- **Why stopped:** No beneficial effects on biomarker or clinical efficacy endpoints in the VGL101-01.201 Study
- **Last updated:** 2025-08-13


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05020743

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05020743, "Natural History Study in Adult-Onset Leukoencephalopathy With Axonal Spheroids and Pigmented Glia". Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/clinical/NCT05020743. Licensed CC0.

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