# LYR-220 for Adult Subjects With Chronic Rhinosinusitis (BEACON Study)

> **NCT05035654** · PHASE2 · COMPLETED · sponsor: **Lyra Therapeutics** · enrollment: 48 (actual)

## Conditions studied

- Chronic Sinusitis
- Chronic Rhinosinusitis (Diagnosis)

## Interventions

- **DRUG:** LYR-220 Design 1 (Part 1 only)
- **DRUG:** LYR-220 Design 2 (Part 1 and Part 2)
- **DRUG:** Bilateral sham procedure control (Part 2)

## Key facts

- **NCT ID:** NCT05035654
- **Lead sponsor:** Lyra Therapeutics
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2021-11-23
- **Primary completion:** 2023-08-30
- **Final completion:** 2023-08-30
- **Target enrollment:** 48 (ACTUAL)
- **Last updated:** 2024-12-17


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05035654

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05035654, "LYR-220 for Adult Subjects With Chronic Rhinosinusitis (BEACON Study)". Retrieved via AI Analytics 2026-06-08 from https://api.ai-analytics.org/clinical/NCT05035654. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*