# Elucidating the Neurocircuitry of Irritability With High-Field Neuroimaging to Identify Novel Therapeutic Targets

> **NCT05046184** · PHASE2 · COMPLETED · sponsor: **University of Texas Southwestern Medical Center** · enrollment: 165 (actual)

## Conditions studied

- Major Depressive Disorder
- Healthy Controls

## Interventions

- **DRUG:** Ketamine Hydrochloride
- **DRUG:** Midazolam injection

## Key facts

- **NCT ID:** NCT05046184
- **Lead sponsor:** University of Texas Southwestern Medical Center
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2022-05-05
- **Primary completion:** 2025-04-30
- **Final completion:** 2025-04-30
- **Target enrollment:** 165 (ACTUAL)
- **Last updated:** 2025-05-08


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05046184

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05046184, "Elucidating the Neurocircuitry of Irritability With High-Field Neuroimaging to Identify Novel Therapeutic Targets". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT05046184. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*