Testing A New Anti-cancer Drug Combination, Entinostat and ZEN003694, for Advanced and Refractory Solid Tumors

NCT05053971 · clinicaltrials.gov ↗

PHASE1,PHASE2

Phase

RECRUITING

Status

49

Enrollment

NIH

Sponsor class

Conditions

Advanced Malignant Solid Neoplasm
Locally Advanced Pancreatic Carcinoma
Metastatic Pancreatic Carcinoma
Refractory Malignant Solid Neoplasm
Refractory Pancreatic Carcinoma
Stage II Pancreatic Cancer AJCC v8
Stage III Pancreatic Cancer AJCC v8
Stage IV Pancreatic Cancer AJCC v8
Unresectable Pancreatic Carcinoma

Interventions

DRUG: BET Bromodomain Inhibitor ZEN-3694
PROCEDURE: Computed Tomography
PROCEDURE: Core Biopsy
DRUG: Entinostat

Sponsor

National Cancer Institute (NCI)