# Shortened vs Standard Chemotherapy Combined With Immunotherapy for the Initial Treatment of Patients With High Tumor Burden Follicular Lymphoma

> **NCT05058404** · PHASE3 · ACTIVE_NOT_RECRUITING · sponsor: **Fondazione Italiana Linfomi - ETS** · enrollment: 605 (actual)

## Conditions studied

- Follicular Lymphoma

## Interventions

- **DRUG:** Immunochemotherapy regimen: Rituximab-bendamustine (Arm A)
- **DRUG:** Immunochemotherapy regimen: Rituximab-bendamustine (Arm B)
- **DRUG:** Immunochemotherapy regimen: R-CHOP (Arm A)
- **DRUG:** Immunochemotherapy regimen: R-CHOP (Arm B)
- **DRUG:** Immunochemotherapy regimen: G-bendamustine (Arm A)
- **DRUG:** Immunochemotherapy regimen: G-bendamustine (Arm B)
- **DRUG:** Immunochemotherapy regimen: G-CHOP (Arm A)
- **DRUG:** Immunochemotherapy regimen: G-CHOP (Arm B)
- **DRUG:** Immunochemotherapy regimen: G-CVP (Arm A)
- **DRUG:** Immunochemotherapy regimen: G-CVP (Arm B)

## Key facts

- **NCT ID:** NCT05058404
- **Lead sponsor:** Fondazione Italiana Linfomi - ETS
- **Sponsor class:** OTHER
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2021-12-01
- **Primary completion:** 2028-07
- **Final completion:** 2030-07
- **Target enrollment:** 605 (ACTUAL)
- **Last updated:** 2025-09-03


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05058404

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05058404, "Shortened vs Standard Chemotherapy Combined With Immunotherapy for the Initial Treatment of Patients With High Tumor Burden Follicular Lymphoma". Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/clinical/NCT05058404. Licensed CC0.

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