# Natural History Study of CADASIL

> **NCT05072483** · — · RECRUITING · sponsor: **National Heart, Lung, and Blood Institute (NHLBI)** · enrollment: 155 (estimated)

## Conditions studied

- Cardiovascular Disease
- Arterial Stiffness
- Germline Mutation in the NOTCH 3 Gene
- Pathogenesis of CADASIL
- Clinical Phenotype of CADASIL

## Interventions

- **DEVICE:** MRI

## Key facts

- **NCT ID:** NCT05072483
- **Lead sponsor:** National Heart, Lung, and Blood Institute (NHLBI)
- **Sponsor class:** NIH
- **Phase:** —
- **Study type:** OBSERVATIONAL
- **Status:** RECRUITING
- **Start date:** 2022-04-18
- **Primary completion:** 2034-06-01
- **Final completion:** 2041-06-01
- **Target enrollment:** 155 (ESTIMATED)
- **Last updated:** 2026-05-14


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05072483

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05072483, "Natural History Study of CADASIL". Retrieved via AI Analytics 2026-07-23 from https://api.ai-analytics.org/clinical/NCT05072483. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*