# Duloxetine RCT on Postop TKA Outcomes

> **NCT05086393** · PHASE4 · COMPLETED · sponsor: **Rush University Medical Center** · enrollment: 241 (actual)

## Conditions studied

- Pain, Postoperative
- Total Knee Arthroplasty

## Interventions

- **DRUG:** Duloxetine
- **DRUG:** Placebos

## Key facts

- **NCT ID:** NCT05086393
- **Lead sponsor:** Rush University Medical Center
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2021-11-01
- **Primary completion:** 2025-06-01
- **Final completion:** 2025-07-23
- **Target enrollment:** 241 (ACTUAL)
- **Last updated:** 2025-11-14


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05086393

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05086393, "Duloxetine RCT on Postop TKA Outcomes". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT05086393. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*