Personalized Neo-Antigen Peptide Vaccine for the Treatment of Stage IIIC-IV Melanoma, Hormone Receptor Positive HER2 Negative Metastatic Refractory Breast Cancer or Stage III-IV Non-Small Cell Lung Cancer
Conditions
- Anatomic Stage IV Breast Cancer AJCC v8
- Clinical Stage IV Cutaneous Melanoma AJCC v8
- Locally Advanced Cutaneous Melanoma
- Locally Advanced Mucosal Melanoma
- Metastatic Acral Melanoma
- Metastatic Conjunctival Melanoma
- Metastatic Cutaneous Melanoma
- Metastatic HER2-Negative Breast Carcinoma
- Metastatic Hormone Receptor-Positive Breast Carcinoma
- Metastatic Lung Non-Small Cell Carcinoma
- Metastatic Malignant Solid Neoplasm
- Metastatic Mucosal Melanoma
- Pathologic Stage IIIC Cutaneous Melanoma AJCC v8
- Pathologic Stage IIID Cutaneous Melanoma AJCC v8
- Recurrent Cutaneous Melanoma
- Recurrent HER2-Negative Breast Carcinoma
- Recurrent Hormone Receptor-Positive Breast Carcinoma
- Recurrent Lung Non-Small Cell Carcinoma
- Recurrent Mucosal Melanoma
- Stage III Lung Cancer AJCC v8
- Stage IV Lung Cancer AJCC v8
- Unresectable Acral Melanoma
- Unresectable Cutaneous Melanoma
- Unresectable Lung Non-Small Cell Carcinoma
- Unresectable Mucosal Melanoma
Interventions
- BIOLOGICAL: Neoantigen Peptide Vaccine
- BIOLOGICAL: Nivolumab
- DRUG: Poly ICLC
- PROCEDURE: Echocardiography
- PROCEDURE: Multigated Acquisition Scan
- PROCEDURE: Biopsy
- PROCEDURE: Biospecimen Collection
- PROCEDURE: Computed Tomography
- PROCEDURE: Positron Emission Tomography
Sponsor
Fred Hutchinson Cancer Center
Collaborators