# Papaverine in Combination With Chemoradiation for the Treatment of Stage II-III Non-small Cell Lung Cancer

> **NCT05136846** · PHASE1 · RECRUITING · sponsor: **Ohio State University Comprehensive Cancer Center** · enrollment: 28 (estimated)

## Conditions studied

- Locally Advanced Lung Non-Small Cell Carcinoma
- Stage II Lung Cancer AJCC v8
- Stage IIA Lung Cancer AJCC v8
- Stage IIB Lung Cancer AJCC v8
- Stage III Lung Cancer AJCC v8
- Stage IIIA Lung Cancer AJCC v8
- Stage IIIB Lung Cancer AJCC v8
- Stage IIIC Lung Cancer AJCC v8
- Unresectable Lung Non-Small Cell Carcinoma

## Interventions

- **DRUG:** Carboplatin
- **BIOLOGICAL:** Durvalumab
- **DRUG:** Paclitaxel
- **DRUG:** Papaverine
- **RADIATION:** Radiation Therapy
- **DRUG:** Pemetrexed
- **RADIATION:** Hypofractionated Radiation Therapy
- **PROCEDURE:** Magnetic Resonance Imaging
- **PROCEDURE:** Positron Emission Tomography
- **PROCEDURE:** Computed Tomography
- **PROCEDURE:** Magnetic Resonance Imaging of the Brain with and without Contrast
- **PROCEDURE:** Biospecimen Collection

## Key facts

- **NCT ID:** NCT05136846
- **Lead sponsor:** Ohio State University Comprehensive Cancer Center
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2021-12-06
- **Primary completion:** 2026-12-31
- **Final completion:** 2026-12-31
- **Target enrollment:** 28 (ESTIMATED)
- **Last updated:** 2025-06-04

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05136846

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05136846, "Papaverine in Combination With Chemoradiation for the Treatment of Stage II-III Non-small Cell Lung Cancer". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT05136846. Licensed CC0.

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