# NIV-MISA-NRDS Trial: a Multicenter Study in China

> **NCT05137340** · NA · TERMINATED · sponsor: **Peking University Third Hospital** · enrollment: 312 (actual)

## Conditions studied

- Minimal Invasive Surfactant Administration in Two Different Non-invasive Ventilation Modes to NRDS Infants

## Interventions

- **OTHER:** Nasal continuous positive airway pressure
- **OTHER:** Non-invasive positive pressure ventilation

## Key facts

- **NCT ID:** NCT05137340
- **Lead sponsor:** Peking University Third Hospital
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2021-12-01
- **Primary completion:** 2025-02-01
- **Final completion:** 2025-03-10
- **Target enrollment:** 312 (ACTUAL)
- **Why stopped:** The trial was terminated early based on interim analysis results indicating futility. The decision was approved by the Data Safety Monitoring Committee (DSMC).
- **Last updated:** 2025-07-09


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05137340

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05137340, "NIV-MISA-NRDS Trial: a Multicenter Study in China". Retrieved via AI Analytics 2026-06-03 from https://api.ai-analytics.org/clinical/NCT05137340. Licensed CC0.

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