# Radiofrequency Ablation Versus I-131 for Solitary Autonomous Thyroid Nodules

> **NCT05142904** · PHASE3 · TERMINATED · sponsor: **Rijnstate Hospital** · enrollment: 40 (actual)

## Conditions studied

- Thyroid Nodule, Toxic or With Hyperthyroidism
- Autonomous Thyroid Function
- Thyroid Nodule; Hyperthyroidism
- Radiofrequency Ablation
- Iodine Hyperthyroidism
- Iodine Adverse Reaction

## Interventions

- **DEVICE:** Radiofrequency ablation
- **DRUG:** Radioactive iodine
- **DRUG:** Radioactive iodine

## Key facts

- **NCT ID:** NCT05142904
- **Lead sponsor:** Rijnstate Hospital
- **Sponsor class:** OTHER
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2021-11-17
- **Primary completion:** 2024-11-01
- **Final completion:** 2024-11-01
- **Target enrollment:** 40 (ACTUAL)
- **Why stopped:** Switched from RCT to observational prospective cohort due to termination of subsidy (delay due to insufficient inclusion-rate). Follow-up of RCT-arm will be completed. Patients can still be included in a observational cohort.
- **Last updated:** 2025-07-17

## Collaborators

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- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05142904

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05142904, "Radiofrequency Ablation Versus I-131 for Solitary Autonomous Thyroid Nodules". Retrieved via AI Analytics 2026-06-26 from https://api.ai-analytics.org/clinical/NCT05142904. Licensed CC0.

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