Highest Dose of Uproleselan in Combination With Fludarabine and Cytarabine for Patients With Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Mixed Phenotype Acute Leukemia Relapsed or Refractory That Expresses E-selectin Ligand on the Cell Membrane

Conditions

• Acute Myeloid Leukemia Post Cytotoxic Therapy
• Myelodysplastic Syndrome Post Cytotoxic Therapy
• Myeloid Leukemia Associated With Down Syndrome
• Recurrent Acute Myeloid Leukemia
• Recurrent Mixed Phenotype Acute Leukemia
• Recurrent Myelodysplastic Syndrome
• Refractory Acute Myeloid Leukemia
• Refractory Mixed Phenotype Acute Leukemia
• Refractory Myelodysplastic Syndrome

Interventions

• DRUG: Cytarabine
• DRUG: Fludarabine
• DRUG: Leucovorin
• DRUG: Triple Intrathecal Chemotherapy
• DRUG: Uproleselan

Sponsor

National Cancer Institute (NCI)

Collaborators

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