# The Effect of Esketamine Combined With Pregabalin on Chronic Postsurgical Pain in Patients After Craniotomy.

> **NCT05160493** · PHASE2,PHASE3 · COMPLETED · sponsor: **Beijing Tiantan Hospital** · enrollment: 246 (actual)

## Conditions studied

- Chronic Postsurgical Pain

## Interventions

- **DRUG:** S-ketamine and pregabalin
- **DRUG:** Normal saline and placebo capsule

## Key facts

- **NCT ID:** NCT05160493
- **Lead sponsor:** Beijing Tiantan Hospital
- **Sponsor class:** OTHER
- **Phase:** PHASE2,PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2021-12-20
- **Primary completion:** 2023-12-11
- **Final completion:** 2024-06-20
- **Target enrollment:** 246 (ACTUAL)
- **Last updated:** 2024-08-01


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05160493

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05160493, "The Effect of Esketamine Combined With Pregabalin on Chronic Postsurgical Pain in Patients After Craniotomy.". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT05160493. Licensed CC0.

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