# ALLIANCE: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve

> **NCT05172960** · NA · ACTIVE_NOT_RECRUITING · sponsor: **Edwards Lifesciences** · enrollment: 915 (actual)

## Conditions studied

- Aortic Stenosis, Severe

## Interventions

- **DEVICE:** SAPIEN X4 THV

## Key facts

- **NCT ID:** NCT05172960
- **Lead sponsor:** Edwards Lifesciences
- **Sponsor class:** INDUSTRY
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2022-06-20
- **Primary completion:** 2025-07-22
- **Final completion:** 2034-12
- **Target enrollment:** 915 (ACTUAL)
- **Last updated:** 2025-08-14


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05172960

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05172960, "ALLIANCE: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT05172960. Licensed CC0.

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