# A Trial to Assess the Effects of Prazosin or Propranolol on Blood Pressure in the Presence of Brexpiprazole/Sertraline

> **NCT05189977** · PHASE1 · TERMINATED · sponsor: **Otsuka Pharmaceutical Development & Commercialization, Inc.** · enrollment: 34 (actual)

## Conditions studied

- Post-traumatic Stress Disorder (PTSD)

## Interventions

- **DRUG:** Propranolol
- **DRUG:** Prazosin

## Key facts

- **NCT ID:** NCT05189977
- **Lead sponsor:** Otsuka Pharmaceutical Development & Commercialization, Inc.
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2022-09-07
- **Primary completion:** 2023-08-03
- **Final completion:** 2023-08-03
- **Target enrollment:** 34 (ACTUAL)
- **Why stopped:** The decision to terminate the trial early was not based on safety concerns. The trial was terminated early due to some implausible blood pressure values being captured, which was the primary endpoint of the study.
- **Last updated:** 2024-01-23

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05189977

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05189977, "A Trial to Assess the Effects of Prazosin or Propranolol on Blood Pressure in the Presence of Brexpiprazole/Sertraline". Retrieved via AI Analytics 2026-06-22 from https://api.ai-analytics.org/clinical/NCT05189977. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*