# Preoperative Short-course Radiation Followed by Envafolimab Plus CAPEOX for MSS Locally Advanced Rectal Adenocarcinoma (PRECAM)

> **NCT05216653** · PHASE2 · COMPLETED · sponsor: **Sir Run Run Shaw Hospital** · enrollment: 32 (actual)

## Conditions studied

- MSS Locally Advanced Rectal Adenocarcinoma

## Interventions

- **DRUG:** Envafolimab
- **DRUG:** Oxaliplatin
- **DRUG:** Capecitabine
- **RADIATION:** Short-course Radiation
- **PROCEDURE:** TME surgery, total mesorectal excision

## Key facts

- **NCT ID:** NCT05216653
- **Lead sponsor:** Sir Run Run Shaw Hospital
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2022-04-07
- **Primary completion:** 2023-03-31
- **Final completion:** 2025-03-05
- **Target enrollment:** 32 (ACTUAL)
- **Last updated:** 2025-03-13


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05216653

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05216653, "Preoperative Short-course Radiation Followed by Envafolimab Plus CAPEOX for MSS Locally Advanced Rectal Adenocarcinoma (PRECAM)". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT05216653. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*