# RESET-medication Glucocorticoid Receptor (GR) Blockade As Disease Modifying Treatment for Depression with Childhood Trauma

> **NCT05217758** · PHASE2 · COMPLETED · sponsor: **Amsterdam UMC, location VUmc** · enrollment: 158 (actual)

## Conditions studied

- Major Depressive Disorder
- Childhood Trauma

## Interventions

- **DRUG:** Mifepristone
- **DRUG:** Placebo

## Key facts

- **NCT ID:** NCT05217758
- **Lead sponsor:** Amsterdam UMC, location VUmc
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2021-12-09
- **Primary completion:** 2024-08-09
- **Final completion:** 2024-11-12
- **Target enrollment:** 158 (ACTUAL)
- **Last updated:** 2024-12-06

## Collaborators

- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05217758

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05217758, "RESET-medication Glucocorticoid Receptor (GR) Blockade As Disease Modifying Treatment for Depression with Childhood Trauma". Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/clinical/NCT05217758. Licensed CC0.

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