# Using the Multiphase Optimization Strategy to Adapt Cognitive Processing Therapy

> **NCT05220137** · NA · ACTIVE_NOT_RECRUITING · sponsor: **VA Office of Research and Development** · enrollment: 270 (actual)

## Conditions studied

- Stress Disorders, Post-Traumatic

## Interventions

- **BEHAVIORAL:** Modified A-B-C: Working with Events, Thoughts, and Feelings
- **BEHAVIORAL:** Challenging Questions
- **BEHAVIORAL:** Patterns of Problematic Thinking
- **BEHAVIORAL:** Challenging Beliefs
- **BEHAVIORAL:** Veteran's choice of Module (Safety/Trust/Power and Control/Esteem/Intimacy)

## Key facts

- **NCT ID:** NCT05220137
- **Lead sponsor:** VA Office of Research and Development
- **Sponsor class:** FED
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2022-08-01
- **Primary completion:** 2026-05-15
- **Final completion:** 2026-05-15
- **Target enrollment:** 270 (ACTUAL)
- **Last updated:** 2026-04-07


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05220137

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05220137, "Using the Multiphase Optimization Strategy to Adapt Cognitive Processing Therapy". Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/clinical/NCT05220137. Licensed CC0.

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