# Buffered vs. Unbuffered Local Anesthesia in Mandibular Molars Diagnosed With Symptomatic Irreversible Pulpitis

> **NCT05227300** · PHASE4 · COMPLETED · sponsor: **Indiana University** · enrollment: 40 (actual)

## Conditions studied

- Symptomatic Irreversible Pulpitis

## Interventions

- **DRUG:** Onset Sodium Bicarbonate Inj., 8.4%, USP Neutralizing Additive Solution
- **DRUG:** 2% lidocaine with 1:100,000 epinephrine

## Key facts

- **NCT ID:** NCT05227300
- **Lead sponsor:** Indiana University
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2022-02-14
- **Primary completion:** 2022-05-23
- **Final completion:** 2022-06-30
- **Target enrollment:** 40 (ACTUAL)
- **Last updated:** 2024-05-14


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05227300

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05227300, "Buffered vs. Unbuffered Local Anesthesia in Mandibular Molars Diagnosed With Symptomatic Irreversible Pulpitis". Retrieved via AI Analytics 2026-08-23 from https://api.ai-analytics.org/clinical/NCT05227300. Licensed CC0.

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