# SMMART Adaptive Clinical Treatment (ACT) Trial

> **NCT05238831** · EARLY_PHASE1 · WITHDRAWN · sponsor: **OHSU Knight Cancer Institute**

## Conditions studied

- Advanced Breast Carcinoma
- Advanced Malignant Solid Neoplasm
- Advanced Ovarian Carcinoma
- Advanced Pancreatic Carcinoma
- Advanced Prostate Carcinoma
- Advanced Sarcoma
- Anatomic Stage III Breast Cancer AJCC v8
- Anatomic Stage IV Breast Cancer AJCC v8
- Recurrent Adult Soft Tissue Sarcoma
- Recurrent Breast Carcinoma
- Recurrent Ovarian Carcinoma
- Recurrent Prostate Carcinoma
- Stage II Pancreatic Cancer AJCC v8
- Stage III Ovarian Cancer AJCC v8
- Stage III Pancreatic Cancer AJCC v8
- Stage IV Ovarian Cancer AJCC v8
- Stage IV Pancreatic Cancer AJCC v8

## Interventions

- **DRUG:** Alectinib
- **DRUG:** Alpelisib
- **DRUG:** Anastrozole
- **BIOLOGICAL:** Atezolizumab
- **BIOLOGICAL:** Bevacizumab
- **PROCEDURE:** Biopsy
- **PROCEDURE:** Biospecimen Collection
- **DRUG:** Capecitabine
- **DRUG:** Carboplatin
- **DRUG:** Cobimetinib
- **DRUG:** Entrectinib
- **DRUG:** Eribulin
- **DRUG:** Fulvestrant
- **BIOLOGICAL:** Hyaluronidase-zzxf/Pertuzumab/Trastuzumab
- **DRUG:** Irinotecan
- **DRUG:** Letrozole
- **DRUG:** Nab-paclitaxel
- **DRUG:** Niraparib
- **DRUG:** Olaparib
- **DRUG:** Paclitaxel

## Key facts

- **NCT ID:** NCT05238831
- **Lead sponsor:** OHSU Knight Cancer Institute
- **Sponsor class:** OTHER
- **Phase:** EARLY_PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** WITHDRAWN
- **Start date:** 2023-01-30
- **Primary completion:** 2026-05-31
- **Final completion:** 2026-05-31
- **Target enrollment:** 0 (ACTUAL)
- **Why stopped:** Withdrawn due to a change in therapeutic interventions.
- **Last updated:** 2024-01-23

## Collaborators

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- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05238831

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05238831, "SMMART Adaptive Clinical Treatment (ACT) Trial". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT05238831. Licensed CC0.

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