# Tolinapant and Radiation for Cisplatin-Ineligible, Previously Untreated, Locally Advanced Head and Neck Cancer

> **NCT05245682** · EARLY_PHASE1 · ACTIVE_NOT_RECRUITING · sponsor: **Emory University** · enrollment: 10 (actual)

## Conditions studied

- Head and Neck Carcinoma of Unknown Primary
- Locally Advanced Head and Neck Squamous Cell Carcinoma
- Locally Advanced Hypopharyngeal Squamous Cell Carcinoma
- Locally Advanced Laryngeal Squamous Cell Carcinoma
- Locally Advanced Nasopharyngeal Squamous Cell Carcinoma
- Locally Advanced Oropharyngeal Squamous Cell Carcinoma

## Interventions

- **DRUG:** Tolinapant
- **RADIATION:** Radiation Therapy

## Key facts

- **NCT ID:** NCT05245682
- **Lead sponsor:** Emory University
- **Sponsor class:** OTHER
- **Phase:** EARLY_PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2022-02-17
- **Primary completion:** 2024-01-15
- **Final completion:** 2026-07-21
- **Target enrollment:** 10 (ACTUAL)
- **Last updated:** 2026-01-08

## Collaborators

- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05245682

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05245682, "Tolinapant and Radiation for Cisplatin-Ineligible, Previously Untreated, Locally Advanced Head and Neck Cancer". Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/clinical/NCT05245682. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*