# Extended-Release Naltrexone and Monthly Extended-Release Buprenorphine for Cocaine Use Disorder (CURB-2)

> **NCT05262270** · PHASE2 · COMPLETED · sponsor: **University of Texas Southwestern Medical Center** · enrollment: 427 (actual)

## Conditions studied

- Cocaine Use Disorder

## Interventions

- **DRUG:** Extended-Release Naltrexone
- **DRUG:** Extended Release Buprenorphine
- **DRUG:** Placebo (PLB) Injectable matched to XR-NTX
- **DRUG:** Placebo (PLB) Injectable matched to XR-BUP

## Key facts

- **NCT ID:** NCT05262270
- **Lead sponsor:** University of Texas Southwestern Medical Center
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2023-04-18
- **Primary completion:** 2025-06-27
- **Final completion:** 2025-07-21
- **Target enrollment:** 427 (ACTUAL)
- **Last updated:** 2025-10-21

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05262270

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05262270, "Extended-Release Naltrexone and Monthly Extended-Release Buprenorphine for Cocaine Use Disorder (CURB-2)". Retrieved via AI Analytics 2026-07-09 from https://api.ai-analytics.org/clinical/NCT05262270. Licensed CC0.

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