# Testing the Addition of Ipatasertib to the Usual Chemotherapy Treatment (Paclitaxel and Carboplatin) for Stage III or IV Epithelial Ovarian Cancer

> **NCT05276973** · PHASE1 · ACTIVE_NOT_RECRUITING · sponsor: **National Cancer Institute (NCI)** · enrollment: 25 (actual)

## Conditions studied

- Fallopian Tube Endometrioid Adenocarcinoma
- Fallopian Tube High Grade Serous Adenocarcinoma
- Ovarian Endometrioid Adenocarcinoma
- Ovarian High Grade Serous Adenocarcinoma
- Primary Peritoneal Endometrioid Adenocarcinoma
- Primary Peritoneal High Grade Serous Adenocarcinoma
- Stage III Fallopian Tube Cancer AJCC v8
- Stage III Ovarian Cancer AJCC v8
- Stage III Primary Peritoneal Cancer AJCC v8
- Stage IV Fallopian Tube Cancer AJCC v8
- Stage IV Ovarian Cancer AJCC v8
- Stage IV Primary Peritoneal Cancer AJCC v8
- Unresectable Fallopian Tube Endometrioid Adenocarcinoma
- Unresectable Fallopian Tube High Grade Serous Adenocarcinoma
- Unresectable Ovarian Endometrioid Adenocarcinoma
- Unresectable Ovarian High Grade Serous Adenocarcinoma
- Unresectable Primary Peritoneal Endometrioid Adenocarcinoma
- Unresectable Primary Peritoneal High Grade Serous Adenocarcinoma

## Interventions

- **PROCEDURE:** Biopsy
- **DRUG:** Carboplatin
- **DRUG:** Ipatasertib
- **DRUG:** Paclitaxel

## Key facts

- **NCT ID:** NCT05276973
- **Lead sponsor:** National Cancer Institute (NCI)
- **Sponsor class:** NIH
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2022-09-08
- **Primary completion:** 2025-01-30
- **Final completion:** 2026-02-26
- **Target enrollment:** 25 (ACTUAL)
- **Last updated:** 2025-12-19

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05276973

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05276973, "Testing the Addition of Ipatasertib to the Usual Chemotherapy Treatment (Paclitaxel and Carboplatin) for Stage III or IV Epithelial Ovarian Cancer". Retrieved via AI Analytics 2026-09-07 from https://api.ai-analytics.org/clinical/NCT05276973. Licensed CC0.

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