# Examining the Effects of Estradiol on Neural and Molecular Response to Reward

> **NCT05282277** · PHASE4 · RECRUITING · sponsor: **University of North Carolina, Chapel Hill** · enrollment: 103 (estimated)

## Conditions studied

- Depression
- Psychosis
- Anhedonia

## Interventions

- **DRUG:** Transdermal Estradiol
- **DRUG:** Micronized Progesterone
- **DRUG:** Matching Placebo Patch
- **DRUG:** Raclopride C11

## Key facts

- **NCT ID:** NCT05282277
- **Lead sponsor:** University of North Carolina, Chapel Hill
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2022-04-20
- **Primary completion:** 2026-12-31
- **Final completion:** 2026-12-31
- **Target enrollment:** 103 (ESTIMATED)
- **Last updated:** 2026-04-29

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05282277

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05282277, "Examining the Effects of Estradiol on Neural and Molecular Response to Reward". Retrieved via AI Analytics 2026-06-04 from https://api.ai-analytics.org/clinical/NCT05282277. Licensed CC0.

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