# Evaluation of the Safety and Effectiveness of Aceclidine/Brimonidine (LNZ101) and Aceclidine (LNZ100) in the Treatment of Presbyopia

> **NCT05294328** · PHASE2 · COMPLETED · sponsor: **LENZ Therapeutics, Inc** · enrollment: 68 (actual)

## Conditions studied

- Presbyopia
- Refractive Errors
- Eye Diseases

## Interventions

- **DRUG:** Aceclidine+Brimonidine combination ophthalmic solution
- **DRUG:** Aceclidine ophthalmic solution
- **DRUG:** Vehicle Proprietary Ophthalmic Solution

## Key facts

- **NCT ID:** NCT05294328
- **Lead sponsor:** LENZ Therapeutics, Inc
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2022-05-05
- **Primary completion:** 2022-08-22
- **Final completion:** 2022-09-10
- **Target enrollment:** 68 (ACTUAL)
- **Last updated:** 2024-09-05


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05294328

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05294328, "Evaluation of the Safety and Effectiveness of Aceclidine/Brimonidine (LNZ101) and Aceclidine (LNZ100) in the Treatment of Presbyopia". Retrieved via AI Analytics 2026-06-26 from https://api.ai-analytics.org/clinical/NCT05294328. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*