# Multi-center RCT of IV Ketamine Efficacy and Safety in Chronic Daily Headaches

> **NCT05306899** · PHASE3 · RECRUITING · sponsor: **University Health Network, Toronto** · enrollment: 56 (estimated)

## Conditions studied

- Chronic Daily Headache

## Interventions

- **DRUG:** Ketamine
- **OTHER:** 0.9% Saline

## Key facts

- **NCT ID:** NCT05306899
- **Lead sponsor:** University Health Network, Toronto
- **Sponsor class:** OTHER
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2022-06-01
- **Primary completion:** 2026-02-01
- **Final completion:** 2026-06-01
- **Target enrollment:** 56 (ESTIMATED)
- **Last updated:** 2026-02-05

## Collaborators

- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05306899

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05306899, "Multi-center RCT of IV Ketamine Efficacy and Safety in Chronic Daily Headaches". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT05306899. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*