# A Study on Using Cell-Free Tumor DNA (ctDNA) Testing to Decide When to StartRoutine Treatment in People With Human Papilloma Virus (HPV)- Associated Oropharynx Cancer (OPC)

> **NCT05307939** · PHASE2 · RECRUITING · sponsor: **Memorial Sloan Kettering Cancer Center** · enrollment: 30 (estimated)

## Conditions studied

- HPV
- Oropharynx Cancer
- HPV-Related Carcinoma
- HPV-Related Malignancy
- HPV Positive Oropharyngeal Squamous Cell Carcinoma

## Interventions

- **DIAGNOSTIC_TEST:** HPV ctDNA Assay
- **DIAGNOSTIC_TEST:** MRI Studies
- **BEHAVIORAL:** EORTC QLQ H&N 35 and C30
- **BEHAVIORAL:** MDADI-HN
- **BEHAVIORAL:** COST-FACIT
- **RADIATION:** Intensity-Modulated Radiation Therapy (Arm A)
- **COMBINATION_PRODUCT:** Chemoradiation (Arm B)

## Key facts

- **NCT ID:** NCT05307939
- **Lead sponsor:** Memorial Sloan Kettering Cancer Center
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2022-03-24
- **Primary completion:** 2027-03-24
- **Final completion:** 2027-03-24
- **Target enrollment:** 30 (ESTIMATED)
- **Last updated:** 2026-04-13


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05307939

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05307939, "A Study on Using Cell-Free Tumor DNA (ctDNA) Testing to Decide When to StartRoutine Treatment in People With Human Papilloma Virus (HPV)- Associated Oropharynx Cancer (OPC)". Retrieved via AI Analytics 2026-09-07 from https://api.ai-analytics.org/clinical/NCT05307939. Licensed CC0.

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