# Early Versus Deferred Aortic Valve Replacement in Patients With Moderate Aortic Stenosis and Mitral Regurgitation

> **NCT05310461** · NA · RECRUITING · sponsor: **Insel Gruppe AG, University Hospital Bern** · enrollment: 80 (estimated)

## Conditions studied

- Aortic Valve Replacement in Patients With Moderate Aortic Stenosis Combined With Mitral Regurgitation

## Interventions

- **PROCEDURE:** Transcatheter or surgical aortic valve replacement with or without transcatheter or surgical mitral valve repair/replacement
- **PROCEDURE:** Deferred treatment, with intervention once AVA is ≤1.0 cm2 or if concomitant mitral regurgitation meets an indication for intervention

## Key facts

- **NCT ID:** NCT05310461
- **Lead sponsor:** Insel Gruppe AG, University Hospital Bern
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2022-08-17
- **Primary completion:** 2024-07-01
- **Final completion:** 2030-01-01
- **Target enrollment:** 80 (ESTIMATED)
- **Last updated:** 2023-11-21


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05310461

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05310461, "Early Versus Deferred Aortic Valve Replacement in Patients With Moderate Aortic Stenosis and Mitral Regurgitation". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT05310461. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*